Module 3 - Unlocking the Potential of HER3-Targeted Therapy: Breakthroughs in EGFR-Mutant NSCLC Therapeutic Approaches

This module discusses the role of HER3-directed ADCs in treating patients with advanced EGFR-mutant NSCLC and adverse events associated with HER3-directed ADCs.

Pasi Jänne, MD

Senior Vice President for Translational Medicine
Dana-Farber Cancer Institute
Boston, MA

Pasi Jänne, MD, PhD, is the Director of the Lower Center for Thoracic Oncology and the David M. Livingston, MD Chair at Dana-Farber Cancer Institute, and a Professor of Medicine at Harvard Medical School. He is also the Director of the Belfer Center for Applied Cancer Science at the Dana-Farber Cancer Institute and Director of the ChenHuang Center for EGFR Mutant Cancers. Dr. Jänne’s research combines laboratory based studies, with translational research and clinical trials of novel therapeutic agents in patients with lung cancer. Furthermore, he has made seminal therapeutic discoveries, including being one of the co-discoverers of EGFR mutations, and findings from his work has led to the development of several clinical trials and new therapies for lung cancer patients.

Jyoti Patel, MD

Professor of Medicine
Northwestern University
Chicago, IL

Jyoti Patel is Professor of Medicine at the Northwestern University. She is the Director of Thoracic Oncology and oversees all lung cancer clinical and research activities. She has devoted her career to improving the lives of those with lung cancer. She has authored numerous publications and has served as the principal investigator of multiple clinical trials. She has been instrumental in developing clinical guidelines for the treatment of lung cancer. In addition, she is Associate Vice Chair of Clinical Research in the Department of Medicine. She has had leadership on national cancer committees including the National Comprehensive Cancer Network, Hoosier Oncology Group, and the Alliance for Clinical Trials in Oncology. She has served the American Society of Clinical Oncology (ASCO) in many educational and scientific capacities over the years.
1.
Describe the biologic and clinical rationale for targeting HER3 and use of HER3-directed ADCs in NSCLC management
2.
Evaluate clinical evidence for HER3-directed ADCs in patients who progress following TKIs or platinum-based chemotherapy in EGFR-mutant NSCLC
3.
Integrate efficacy and safety data on HER3-directed agents and/or combinations into sequencing considerations for patients with progressive stage NSCLC